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Immune Peptide

Thymosin Alpha-1

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Thymosin Alpha-1 is a naturally occurring 28-amino acid peptide derived from the thymus gland, studied for its immunomodulatory effects including T-cell maturation and immune system regulation.

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Description

What is Thymosin Alpha-1?

Thymosin Alpha-1 (Tα1) is a naturally occurring 28-amino acid peptide originally isolated from thymic tissue. It is a key component of Thymosin Fraction 5, a partially purified extract from the thymus gland that was first characterized in the 1970s.

Tα1 plays a central role in immune system regulation, primarily through its effects on T-cell maturation and differentiation. It acts on toll-like receptors (TLR2, TLR9) on dendritic cells and enhances the immune system’s ability to respond to infections and tumors.

A synthetic version of Tα1 has been approved in over 35 countries for the treatment of hepatitis B and C, and as an immune adjuvant. It has not received FDA approval, though it has received orphan drug designation.

Research-grade Thymosin Alpha-1 is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Immunity

T-Cell Maturation & Immunity

Studied for its role in promoting T-cell differentiation and enhancing adaptive immune responses through toll-like receptor activation.

Infection

Infectious Disease Research

Investigated and approved in multiple countries as an adjunct treatment for chronic hepatitis B and C infections.

Cancer Research

Cancer Immunology

Explored as an immunotherapy adjuvant to enhance anti-tumor immune responses in combination with other treatments.

Vaccine Research

Vaccine Enhancement

Studied for its ability to improve vaccine efficacy by enhancing dendritic cell function and antigen presentation.

Compound Profile

Technical specifications

What is Thymosin Alpha-1?

Molecular Profile

Sequence

Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN

Molecular Formula

C₁₂₉H₂₁₅N₃₃O₅₅

Molecular Weight

3,108.28 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C and use within 7 days. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not FDA approved. Approved in 35+ countries as a brand name for hepatitis B/C and as immune adjuvant. Has FDA orphan drug designation.

WADA Classification

Not currently listed as a prohibited substance.

Clinical Trial Status

Hundreds of published studies on immune modulation, T-cell biology, vaccine adjuvancy, and infectious disease.

Published Studies

Hundreds of published studies on immune modulation, T-cell biology, vaccine adjuvancy, and infectious disease.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.69%

Purity

Variant

Thymosin Alpha-1

Lot #

GLZ-THYMOSIN-ALPHA-1-10MG-A

Labelled

10mg

Actual

9.46mg

Tested

3/29/2026

View COA

Frequently Asked Questions

Common questions about Thymosin Alpha-1 research

What is Thymosin Alpha-1?

Thymosin Alpha-1 is a naturally occurring 28-amino acid peptide from the thymus gland that plays a central role in immune regulation, particularly T-cell maturation and differentiation.

Is Thymosin Alpha-1 approved in any country?

Yes. Under its pharmaceutical name thymalfasin, it is approved in over 35 countries for hepatitis B/C treatment and as an immune adjuvant. It holds FDA orphan drug designation but is not currently FDA approved in the United States.

How should Thymosin Alpha-1 be stored?

Lyophilized Thymosin Alpha-1 should be stored below -18°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 7 days.

What is the difference between Thymosin Alpha-1 and Thymosin Beta-4?

Both are thymus-derived peptides but have different structures and functions. Tα1 is a 28-amino acid immune modulator. Tβ4 (TB-500) is a 43-amino acid tissue repair peptide involved in actin regulation and wound healing.

Is Thymosin Alpha-1 FDA approved?

No. While it has FDA orphan drug designation and is approved in 35+ countries, Thymosin Alpha-1 is not FDA approved. Research-grade product is sold for laboratory purposes only.

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Every batch is independently tested, documented, and tied to a specific lot number prior to release. If documentation is missing or inconsistent, we will make it right.

Thymosin Alpha-1

Description