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Sleep Peptide

DSIP

4.7 (64 reviews)

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide studied for its role in sleep regulation, stress modulation, and neuroendocrine function in preclinical research models.

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Description

What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from rabbit brain tissue in 1977. It consists of nine amino acids and was named for its ability to induce delta (slow-wave) sleep in animal models when administered to the brain.

DSIP is found in both the brain and peripheral tissues, and acts as a neuromodulator with effects on multiple physiological systems. Beyond sleep regulation, it has been studied for stress modulation, pain perception, hormone regulation, and antioxidant activity.

Despite its name, the exact mechanisms by which DSIP influences sleep architecture remain an active area of research. It appears to modulate several neurotransmitter and neuroendocrine systems rather than acting through a single sleep-specific pathway.

DSIP is not approved by the FDA for any medical use. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Sleep

Sleep Architecture Research

Studied for its ability to promote delta (slow-wave) sleep and normalize disrupted sleep patterns in animal models.

Stress

Stress & Cortisol Modulation

Investigated for its effects on the hypothalamic-pituitary-adrenal axis and stress hormone regulation.

Hormonal Balance

Neuroendocrine Function

Researched for modulatory effects on multiple hormone systems including LH, GH, and cortisol.

Pain Research

Pain & Nociception Research

Explored in preclinical models for analgesic properties and modulation of pain perception pathways.

Compound Profile

Technical specifications

What is DSIP?

Molecular Profile

Sequence

WAGGDASGE

Molecular Formula

C₃₅H₄₈N₁₀O₁₅

Molecular Weight

848.81 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C and use within 7 days. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved for human use.

WADA Classification

Not currently specifically listed as a prohibited substance.

Clinical Trial Status

Preclinical and early clinical studies on sleep architecture, stress response, pain modulation, and neuroendocrine regulation.

Published Studies

Preclinical and early clinical studies on sleep architecture, stress response, pain modulation, and neuroendocrine regulation.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.73%

Purity

Variant

DSIP

Lot #

GLZ-DSIP-5MG-A

Labelled

5mg

Actual

4.83mg

Tested

3/29/2026

View COA

Frequently Asked Questions

Common questions about DSIP research

What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring 9-amino acid peptide first isolated from rabbit brain tissue in 1977. It is named for its ability to promote delta (slow-wave) sleep in animal models.

How does DSIP promote sleep?

The exact mechanisms remain an active area of research. DSIP appears to modulate multiple neurotransmitter and neuroendocrine systems involved in sleep regulation rather than acting through a single pathway.

How should DSIP be stored?

Lyophilized DSIP should be stored below -18°C, away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 2–8°C and use within 7 days.

Has DSIP been tested in humans?

Limited clinical studies have been conducted primarily in Europe, showing effects on sleep quality and stress markers. No FDA-evaluated clinical trials have been completed.

Is DSIP FDA approved?

No. DSIP is not approved by the FDA for any medical use. It is sold for laboratory and research purposes only.

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Every batch is independently tested, documented, and tied to a specific lot number prior to release. If documentation is missing or inconsistent, we will make it right.

DSIP

Description