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Melanocortin Peptide

Melanotan II

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MT-2 (Melanotan II) is a synthetic cyclic heptapeptide analog of alpha-MSH that activates multiple melanocortin receptors, studied for effects on pigmentation, sexual function, and appetite.

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Description

What is Melanotan II?

Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It consists of seven amino acids in a cyclic structure that provides enhanced stability and receptor binding compared to the natural hormone.

Unlike the linear MT-1, Melanotan II has a broader receptor activity profile, acting on multiple melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). This wider activity accounts for its effects on pigmentation (MC1R), sexual function (MC3R/MC4R), and appetite regulation (MC4R).

MT-2 has not been approved by any regulatory agency for medical use. A derivative of its MC4R-binding properties, bremelanotide (PT-141), was developed separately and received FDA approval for hypoactive sexual desire disorder.

MT-2 is not approved by the FDA for any medical use. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Pigmentation

Melanogenesis & Pigmentation

Studied for potent stimulation of melanin production through MC1R activation, resulting in increased skin pigmentation.

Sexual Health

Sexual Function Research

Investigated for effects on sexual arousal and desire through MC3R/MC4R pathway activation in the central nervous system.

Appetite

Appetite & Energy Balance

Researched for MC4R-mediated effects on appetite suppression and energy homeostasis in preclinical models.

Receptor Research

Melanocortin Receptor Pharmacology

Used as a research tool to study melanocortin receptor subtypes, signaling pathways, and structure-activity relationships.

Compound Profile

Technical specifications

What is Melanotan II?

Molecular Profile

Sequence

Ac-Nle-c[Asp-His-D Phe-Arg-Trp-Lys] NH₂

Molecular Formula

C₅₀H₆₉N₁₅O₉

Molecular Weight

1,024.18 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved for human use.

WADA Classification

Prohibited under class S0 (Non-Approved Substances).

Clinical Trial Status

Preclinical and early clinical studies on melanogenesis, sexual function, appetite modulation, and melanocortin receptor pharmacology.

Published Studies

Preclinical and early clinical studies on melanogenesis, sexual function, appetite modulation, and melanocortin receptor pharmacology.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.38%

Purity

Variant

Melanotan-2

Lot #

GLZ-MT-2-10MG-A

Labelled

10mg

Actual

10.74mg

Tested

2/9/2026

View COA

Frequently Asked Questions

Common questions about Melanotan II research

What is MT-2?

Melanotan II (MT-2) is a synthetic cyclic peptide analog of alpha-MSH that activates multiple melanocortin receptors. It was developed to study the effects on pigmentation, sexual function, and appetite.

How does MT-2 differ from MT-1?

MT-2 is a cyclic heptapeptide with broader melanocortin receptor activity (MC1R, MC3R, MC4R, MC5R), while MT-1 is a linear 13-amino acid peptide with more selective MC1R activity focused on pigmentation.

How should MT-2 be stored?

Lyophilized MT-2 should be stored below -18°C, away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 2–8°C and use within 7 days.

What is the relationship between MT-2 and PT-141?

PT-141 (bremelanotide) was derived from MT-2 research. It is a metabolite of MT-2 that was developed separately and received FDA approval for hypoactive sexual desire disorder.

Is MT-2 FDA approved?

No. MT-2 is not approved by the FDA or any regulatory agency for human use. It is prohibited by WADA. All products are sold for research purposes only.

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Melanotan II

Description