TB-500 10mg Certificate of Analysis 12-11-25

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Regenerative Peptide

TB-500

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TB-500 (Thymosin Beta-4) is a synthetic 43-amino acid peptide derived from a naturally occurring protein involved in cell migration, tissue repair, and new blood vessel formation in preclinical research models.

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Description

What is TB-500?

TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring protein found in nearly all human and animal cells. It is one of the most abundant intracellular proteins and plays a critical role in the regulation of actin, a key component of cellular structure involved in cell movement and tissue repair.

Originally identified in the thymus gland, Thymosin Beta-4 has been extensively studied in preclinical models for its role in promoting cell migration, wound healing, and new blood vessel formation (angiogenesis). TB-500 is distinguished by its low molecular weight and water solubility, which allow it to travel through tissues efficiently in laboratory settings.

Preclinical research has explored TB-500 across wound healing, cardiac tissue recovery, inflammation modulation, and corneal repair. Its primary mechanism involves the sequestration of G-actin monomers and regulation of actin polymerization, essential for cellular motility and tissue remodeling.

TB-500 is not approved by the FDA for any medical use and is prohibited by WADA. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Healing

Tissue Repair & Wound Healing

Studied for its ability to promote cell migration and accelerate wound closure in preclinical injury models.

Blood Flow

Angiogenesis & Blood Vessel Formation

Investigated for promoting new blood vessel growth through VEGF upregulation and endothelial cell migration.

Recovery

Inflammation Modulation

Researched for its anti-inflammatory properties and ability to reduce pro-inflammatory cytokine production.

Heart Health

Cardiac Tissue Research

Explored in preclinical models for its potential to support heart muscle recovery following ischemic events.

Flexibility

Musculoskeletal Research

Studied in animal models for effects on tendon, ligament, and muscle repair and flexibility.

Compound Profile

Technical specifications

What is TB-500?

Molecular Profile

Sequence

Ac-SDKPDMAE IEKFDKSKL KKTETQEKN PLPSKETIE QEKQAGES

Molecular Formula

C₂₁₂H₃₅₀N₅₆O₇₈S

Molecular Weight

4,963.44 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture. Stable at room temperature for up to 3 weeks.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Contains methionine residue susceptible to oxidation. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved for human use. Category 2 bulk drug substance.

WADA Classification

Prohibited under class S0 (Non-Approved Substances).

Clinical Trial Status

Extensive preclinical research in animal models covering wound healing, cardiac repair, and tissue regeneration.

Published Studies

Extensive preclinical research in animal models covering wound healing, cardiac repair, and tissue regeneration.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

97.76%

Purity

Variant

Thymosin Beta-4

Lot #

TB-500-10MG-A

Labelled

10mg

Actual

12.72mg

Tested

12/12/2025

View COA

Frequently Asked Questions

Common questions about TB-500 research

What is TB-500?

TB-500 is a synthetic version of Thymosin Beta-4, a 43-amino acid protein found naturally in nearly all human and animal cells. It has been extensively studied in preclinical research for its role in cell migration, tissue repair, and blood vessel formation.

What areas of research has TB-500 been studied in?

Preclinical studies have investigated TB-500 across wound healing, cardiac tissue repair, inflammation modulation, musculoskeletal recovery, and angiogenesis. The majority of published research has been conducted in animal models.

How should TB-500 be stored?

Lyophilized TB-500 should be stored below -18°C, away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 2–8°C and use within 10–14 days.

What solvent is used to reconstitute TB-500?

TB-500 is typically reconstituted using bacteriostatic water. Always follow your specific research protocol for reconstitution volumes.

Is TB-500 FDA approved?

No. TB-500 is not approved by the FDA for any medical use. It is classified as a Category 2 bulk drug substance and is prohibited by WADA. All products are sold for research purposes only.

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TB-500

Description