NAD+ 500mg Certificate of Analysis 12-11-25

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Longevity Compound

NAD+

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NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for energy metabolism, DNA repair, and cellular signaling, studied for its role in aging and metabolic health.

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Description

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every living cell that plays a fundamental role in cellular metabolism. It exists in two forms: NAD+ (oxidized) and NADH (reduced), and participates in hundreds of metabolic reactions including energy production, DNA repair, and gene expression regulation.

NAD+ levels naturally decline with age, and this decline has been linked to various age-related conditions in preclinical research. This has generated significant interest in NAD+ supplementation as a potential strategy for supporting cellular health and longevity.

NAD+ is a critical cofactor for sirtuins (SIRT1-7), a family of proteins involved in cellular stress response, inflammation regulation, and metabolic adaptation. It is also essential for PARP enzymes involved in DNA damage repair.

Research-grade NAD+ is sold as a lyophilized powder for laboratory and research purposes only.

Research Applications

Areas of Investigation

Energy

Cellular Energy Metabolism

Essential cofactor in glycolysis, the citric acid cycle, and oxidative phosphorylation, the primary pathways cells use to produce energy.

DNA Repair

DNA Repair & Genomic Stability

Required by PARP enzymes for DNA damage detection and repair, supporting genomic integrity.

Longevity

Sirtuin Activation & Longevity

Serves as the essential substrate for sirtuin enzymes (SIRT1-7), which regulate inflammation, stress response, and metabolic adaptation.

Mitochondria

Mitochondrial Function

Studied for its role in maintaining mitochondrial health and bioenergetic capacity, both of which decline with age.

Compound Profile

Technical specifications

What is NAD+?

Molecular Profile

Sequence

N/A, Not a peptide (dinucleotide coenzyme)

Molecular Formula

C₂₁H₂₇N₇O₁₄P₂

Molecular Weight

663.43 g/mol

Appearance

White to off-white lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -20°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. NAD+ is sensitive to degradation in solution. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Highly sensitive to heat, light, moisture, and pH changes. Degrades rapidly in aqueous solution at elevated temperatures.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved as a drug. Available as a dietary supplement ingredient. Research-grade product is for laboratory use only.

WADA Classification

Not currently listed as a prohibited substance.

Clinical Trial Status

Thousands of published studies on NAD+ biology, sirtuin activation, DNA repair, mitochondrial function, and aging.

Published Studies

Thousands of published studies on NAD+ biology, sirtuin activation, DNA repair, mitochondrial function, and aging.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.90%

Purity

Variant

NAD+

Lot #

GLZ-NAD+-500MG-A

Labelled

500mg

Actual

500.61mg

Tested

12/12/2025

View COA

Frequently Asked Questions

Common questions about NAD+ research

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell that is essential for energy metabolism, DNA repair, and cellular signaling. Its levels naturally decline with age.

Is NAD+ a peptide?

No. NAD+ is a dinucleotide coenzyme, not a peptide. It is included in research catalogs because of its significant role in cellular biology and aging research.

How should NAD+ be stored?

Lyophilized NAD+ should be stored below -20°C, protected from light and moisture. It degrades rapidly in aqueous solution, so reconstituted preparations should be used promptly.

What is the relationship between NAD+, NMN, and NR?

NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are precursors that the body converts into NAD+. They are often studied as alternative strategies for raising NAD+ levels.

Is NAD+ FDA approved?

NAD+ is not approved as a drug. It is available as a dietary supplement ingredient in some forms. Research-grade NAD+ is sold for laboratory purposes only.

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NAD+

Description