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Metabolic Peptide

GLP-3 RT 10mg

4.8 (482 reviews)

Retatrutide is a 39-amino acid triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, studied in clinical trials for its effects on weight reduction and metabolic regulation.

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Description

What is GLP-3 RT 10mg?

GLP-3 Retatrutide (LY3437943) is a synthetic 39-amino acid peptide that acts as a triple agonist of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

By targeting three metabolic receptors simultaneously, retatrutide represents the next evolution beyond dual-action peptides like tirzepatide. The glucagon receptor component adds the potential for increased energy expenditure and fat breakdown, while GIP and GLP-1 activation address insulin secretion and appetite regulation.

In Phase II clinical trials, retatrutide demonstrated substantial weight reduction, with some participants achieving over 24% body weight loss over 48 weeks. Phase III trials are currently underway.

Retatrutide is not approved by the FDA for any medical use. Research-grade product is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Triple Action

Triple Receptor Agonism

The first triple-acting peptide targeting GLP-1, GIP, and glucagon receptors simultaneously for synergistic metabolic effects.

Weight Loss

Body Weight Reduction

Demonstrated substantial weight loss in Phase II trials, with some participants achieving over 24% body weight reduction.

Fat Burning

Energy Expenditure

Glucagon receptor activation is studied for its potential to increase thermogenesis and fat oxidation.

Blood Sugar

Glucose Regulation

Investigated for glucose-lowering effects through combined GLP-1 and GIP receptor activation.

Liver Health

Under evaluation for effects on metabolic dysfunction-associated steatotic liver disease in clinical trials.

Compound Profile

Technical specifications

What is GLP-3 RT 10mg?

Molecular Profile

Sequence

YXQGTFTSDYSIxLLDKK*AQXAFIEYLLEGGPSSGAPPPS-NH₂

Molecular Formula

C₂₂₁H₃₄₂N₄₆O₆₈

Molecular Weight

4,731.33 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -20°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C and use within 7 days. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved for human use. Investigational compound in active clinical trials.

WADA Classification

Not currently listed (subject to change as regulatory status evolves).

Clinical Trial Status

Growing body of preclinical and clinical research on triple-receptor agonism, weight management, and metabolic outcomes.

Published Studies

Growing body of preclinical and clinical research on triple-receptor agonism, weight management, and metabolic outcomes.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.87%

Purity

Variant

GLP RT

Lot #

GLZ-GLP-3-RT-15MG-A

Labelled

10mg

Actual

11.41mg

Tested

3/29/2026

View COA

Frequently Asked Questions

Common questions about GLP-3 RT 10mg research

What is Retatrutide?

Retatrutide is a synthetic 39-amino acid peptide that targets three metabolic receptors: GLP-1, GIP, and glucagon.

How does Retatrutide differ from Semaglutide and Tirzepatide?

Semaglutide targets only GLP-1. Tirzepatide targets GLP-1 and GIP. Retatrutide adds a third target, the glucagon receptor, which may contribute to increased energy expenditure and fat metabolism.

How should Retatrutide be stored?

Lyophilized retatrutide should be stored below -20°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 7 days.

What clinical trials have been conducted?

Phase II trials showed significant weight loss and metabolic improvements. Phase III trials are currently underway for obesity, type 2 diabetes, and liver disease.

Is Retatrutide FDA approved?

No. Retatrutide is an investigational compound not approved by the FDA. It is sold for laboratory and research purposes only.

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Every batch is independently tested, documented, and tied to a specific lot number prior to release. If documentation is missing or inconsistent, we will make it right.

GLP-3 RT 10mg

Description