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Anti-Aging Peptide

GHK-Cu

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GHK-Cu is a naturally occurring copper-binding tripeptide studied for its roles in collagen synthesis, wound healing, anti-inflammatory signaling, and gene expression modulation in preclinical research.

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Description

What is GHK-Cu?

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring tripeptide–copper complex first isolated from human plasma in 1973. It consists of three amino acids, glycine, histidine, and lysine, bound to a copper (II) ion with high affinity.

GHK-Cu is found naturally in human plasma, saliva, and urine, with levels declining significantly with age, from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60. This age-related decline has driven significant research interest in the peptide’s potential regenerative properties.

In preclinical research, GHK-Cu has demonstrated the ability to stimulate collagen synthesis, promote wound healing, attract immune cells, provide antioxidant and anti-inflammatory effects, and promote blood vessel growth. Recent genomic studies have revealed its ability to modulate the expression of thousands of human genes.

GHK-Cu is widely used in cosmetic formulations as an anti-aging ingredient. Research-grade GHK-Cu is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Skin Health

Collagen & Skin Research

Studied for its ability to stimulate collagen and glycosaminoglycan synthesis in fibroblast models, supporting skin structure and elasticity.

Healing

Wound Healing

Investigated in preclinical models for accelerating wound contraction, epithelialization, and tissue remodeling.

Gene Activity

Gene Expression Modulation

Recent genomic studies show GHK-Cu can modulate the expression of thousands of human genes involved in repair, inflammation, and aging.

Protection

Anti-Inflammatory & Antioxidant

Researched for its ability to suppress inflammatory cytokines, reduce oxidative damage, and protect tissues from free radical injury.

Compound Profile

Technical specifications

What is GHK-Cu?

Molecular Profile

Sequence

Gly-His-Lys (Cu²⁺ complex)

Molecular Formula

C₁₄H₂₃CuN₆O₄

Molecular Weight

401.91 g/mol

Appearance

Blue-green lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Copper complex may be affected by pH changes in solution.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved as a drug. Used in cosmetic formulations (INCI: Copper Tripeptide-1). Not regulated as a pharmaceutical.

WADA Classification

Not currently listed as a prohibited substance.

Clinical Trial Status

Extensive preclinical research on wound healing, collagen synthesis, gene expression modulation, and anti-inflammatory effects.

Published Studies

Extensive preclinical research on wound healing, collagen synthesis, gene expression modulation, and anti-inflammatory effects.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.92%

Purity

Variant

GHK-Cu

Lot #

GLZ-GHK-Cu-50MG-A

Labelled

50mg

Actual

58.75mg

Tested

2/9/2026

View COA

Frequently Asked Questions

Common questions about GHK-Cu research

What is GHK-Cu?

GHK-Cu is a naturally occurring tripeptide (glycine-histidine-lysine) bound to copper. First isolated from human plasma in 1973, it is studied for its roles in tissue repair, collagen production, and gene expression modulation.

Why does GHK-Cu appear blue-green?

The blue-green color comes from the copper (II) ion complexed with the peptide. This is normal and indicates the presence of the copper component essential to the peptide's activity.

How should GHK-Cu be stored?

Lyophilized GHK-Cu should be stored below -18°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 14 days.

What solvent is used to reconstitute GHK-Cu?

GHK-Cu may have limited solubility in bacteriostatic water alone. Researchers often begin with a small volume of 0.6% acetic acid before diluting with bacteriostatic water for improved dissolution.

Is GHK-Cu FDA approved?

No. GHK-Cu is not approved as a pharmaceutical drug. It is widely used in cosmetic formulations and is sold as a research peptide for laboratory purposes only.

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Every batch is independently tested, documented, and tied to a specific lot number prior to release. If documentation is missing or inconsistent, we will make it right.

GHK-Cu

Description