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Longevity Peptide

MOTS-C

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MOTS-c is a mitochondria-derived 16-amino acid peptide encoded within mitochondrial DNA, studied for its effects on metabolic homeostasis, insulin sensitivity, and exercise-induced signaling.

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Description

What is MOTS-C?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded within the mitochondrial genome, making it one of the few known mitochondria-derived peptides (MDPs).

MOTS-c is unique because it is encoded by mitochondrial DNA rather than nuclear DNA, representing a form of mitochondrial-nuclear communication. It is released into the bloodstream where it acts as a signaling molecule that regulates metabolic homeostasis.

In preclinical research, MOTS-c has demonstrated effects on glucose regulation, fatty acid metabolism, and AMPK activation. It has also shown exercise-mimetic properties, with levels increasing during physical activity. Studies in aged mice showed improvements in physical capacity and metabolic function.

MOTS-c is not approved by the FDA for any medical use. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Metabolism

Metabolic Homeostasis

Studied for its ability to regulate glucose metabolism and fatty acid oxidation through AMPK pathway activation.

Longevity

Exercise & Aging Research

Investigated as an exercise-responsive factor that declines with age, with potential implications for age-related metabolic decline.

Blood Sugar

Insulin Sensitivity

Researched for improvements in insulin sensitivity and glucose uptake in preclinical models of metabolic dysfunction.

Mitochondria

Mitochondrial Signaling

Explored as a mitochondria-derived peptide that mediates communication between mitochondria and the nucleus.

Compound Profile

Technical specifications

What is MOTS-C?

Molecular Profile

Sequence

MRWQEMGYIFYPRKL R

Molecular Formula

C₁₀₁H₁₅₂N₂₈O₂₂S₂

Molecular Weight

2,174.58 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -20°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Contains methionine residues susceptible to oxidation. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved for human use. Recently discovered research peptide.

WADA Classification

Not currently specifically listed as a prohibited substance.

Clinical Trial Status

Growing body of preclinical research on metabolic regulation, exercise physiology, insulin sensitivity, and aging.

Published Studies

Growing body of preclinical research on metabolic regulation, exercise physiology, insulin sensitivity, and aging.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.25%

Purity

Variant

MOTS-C

Lot #

GLZ-MOTS-C-10MG-A

Labelled

10mg

Actual

10.20mg

Tested

3/29/2026

View COA

Frequently Asked Questions

Common questions about MOTS-C research

What is MOTS-c?

MOTS-c is a 16-amino acid peptide encoded within mitochondrial DNA, discovered in 2015. It regulates metabolic homeostasis and has been described as an exercise-responsive signaling molecule.

What makes MOTS-c unique among peptides?

MOTS-c is one of the few known peptides encoded by mitochondrial DNA rather than nuclear DNA. It represents a form of retrograde signaling from mitochondria to the rest of the cell and body.

How should MOTS-c be stored?

Lyophilized MOTS-c should be stored below -20°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 7 days.

Has MOTS-c been tested in humans?

Human clinical trials are in early stages. Most published research has been conducted in preclinical (animal) models and cell culture studies.

Is MOTS-c FDA approved?

No. MOTS-c is not approved by the FDA for any medical use. It is a recently discovered peptide sold for laboratory and research purposes only.

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Every batch is independently tested, documented, and tied to a specific lot number prior to release. If documentation is missing or inconsistent, we will make it right.

MOTS-C

Description