PT-141
-23%
4X Tested - ISO 17025
99.93% View COA
Melanocortin Peptide

PT-141

Certificate of Analysis

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist derived from Melanotan II, FDA-approved for hypoactive sexual desire disorder and studied for its effects on sexual function.

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Description

What is PT-141?

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide that acts as an agonist of melanocortin receptors, primarily MC4R and MC3R, in the central nervous system. It was derived from research on Melanotan II and developed specifically for its effects on sexual function.

Unlike phosphodiesterase inhibitors that work on vascular mechanisms, PT-141 acts centrally through melanocortin pathways in the brain to modulate sexual desire and arousal. This unique mechanism of action represents a different approach to sexual dysfunction research.

PT-141 was approved by the FDA in 2019 for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. It is the only FDA-approved medication that works through melanocortin receptor pathways for this indication.

Research Applications

Areas of Investigation
Sexual Health

Sexual Function Research

FDA-approved for HSDD through MC4R/MC3R activation in the CNS, representing a unique mechanism distinct from vascular-based approaches.
Receptor Research

Melanocortin Receptor Pharmacology

Studied as a tool compound for understanding MC3R and MC4R signaling pathways in the central nervous system.
CNS Signaling

Central Nervous System Signaling

Investigated for its central mechanism of action in modulating desire and arousal through hypothalamic melanocortin circuits.

Compound Profile

Technical specifications
What is PT-141?

Molecular Profile

Sequence
Ac-n-c[DH-f-RWK]-OH
Molecular Formula
C₅₀H₆₈N₁₄O₁₀
Molecular Weight
1,025.17 g/mol
Appearance
White lyophilized powder

Form

Lyophilized (freeze-dried)
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.
Shelf Life
24 months from date of manufacture when stored as directed
Sensitivity Notes
Sensitive to heat, light, and moisture. Keep sealed until use.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
FDA-approved as a brand name for hypoactive sexual desire disorder (HSDD) in premenopausal women. Research-grade product is not equivalent.
WADA Classification
Not currently specifically listed as a prohibited substance.
Clinical Trial Status
Published clinical and preclinical studies on melanocortin-mediated sexual function, arousal, and desire.
Published Studies
Published clinical and preclinical studies on melanocortin-mediated sexual function, arousal, and desire.
Research Disclaimer
Research-grade product is for laboratory purposes only. Not equivalent to FDA-approved brand. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
99.93%
Purity
Variant
PT-141
Lot #
GL-2609-033
Labelled
10mg
Actual
10.51mg
Tested
9/14/2026
View COA
(opens in a new tab)
99.96%
Purity
Variant
PT-141
Lot #
PF14110-GL01
Labelled
10mg
Actual
10.66mg
Tested
6/24/2026
View COA
(opens in a new tab)
99.67%
Purity
Variant
PT-141
Lot #
GLZ-PT-141-10MG-A
Labelled
10mg
Actual
8.68mg
Tested
3/29/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about PT-141 research