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Melanocortin Peptide

PT-141

4.8 (32 reviews)

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist derived from Melanotan II, FDA-approved for hypoactive sexual desire disorder and studied for its effects on sexual function.

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Description

What is PT-141?

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide that acts as an agonist of melanocortin receptors, primarily MC4R and MC3R, in the central nervous system. It was derived from research on Melanotan II and developed specifically for its effects on sexual function.

Unlike phosphodiesterase inhibitors that work on vascular mechanisms, PT-141 acts centrally through melanocortin pathways in the brain to modulate sexual desire and arousal. This unique mechanism of action represents a different approach to sexual dysfunction research.

PT-141 was approved by the FDA in 2019 for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. It is the only FDA-approved medication that works through melanocortin receptor pathways for this indication.

Research Applications

Areas of Investigation

Sexual Health

Sexual Function Research

FDA-approved for HSDD through MC4R/MC3R activation in the CNS, representing a unique mechanism distinct from vascular-based approaches.

Receptor Research

Melanocortin Receptor Pharmacology

Studied as a tool compound for understanding MC3R and MC4R signaling pathways in the central nervous system.

CNS Signaling

Central Nervous System Signaling

Investigated for its central mechanism of action in modulating desire and arousal through hypothalamic melanocortin circuits.

Compound Profile

Technical specifications

What is PT-141?

Molecular Profile

Sequence

Ac-n-c[DH-f-RWK]-OH

Molecular Formula

C₅₀H₆₈N₁₄O₁₀

Molecular Weight

1,025.17 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

FDA-approved as a brand name for hypoactive sexual desire disorder (HSDD) in premenopausal women. Research-grade product is not equivalent.

WADA Classification

Not currently specifically listed as a prohibited substance.

Clinical Trial Status

Published clinical and preclinical studies on melanocortin-mediated sexual function, arousal, and desire.

Published Studies

Published clinical and preclinical studies on melanocortin-mediated sexual function, arousal, and desire.

Research Disclaimer

Research-grade product is for laboratory purposes only. Not equivalent to FDA-approved brand. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.67%

Purity

Variant

PT-141

Lot #

GLZ-PT-141-10MG-A

Labelled

10mg

Actual

8.68mg

Tested

3/29/2026

View COA

Frequently Asked Questions

Common questions about PT-141 research

What is PT-141?

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist derived from Melanotan II. It is used for hypoactive sexual desire disorder in premenopausal women.

How does PT-141 work?

Unlike vascular-based medications, PT-141 acts centrally in the brain through melanocortin receptor pathways (MC3R/MC4R) to modulate sexual desire and arousal.

How should PT-141 be stored?

Lyophilized PT-141 should be stored below -18°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 7 days.

What is the relationship between PT-141 and MT-2?

PT-141 was derived from research on Melanotan II. It is a metabolite of MT-2 that was developed separately for its specific effects on sexual function through melanocortin pathways.

Is research-grade PT-141 FDA approved?

No. Research-grade PT-141 is not the same as FDA-approved brand. It is sold for laboratory and research purposes only.

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PT-141

Description