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Reproductive Neuropeptide

Kisspeptin

4.8 (24 reviews)

Kisspeptin-10 is a neuropeptide that activates the GPR54 receptor, studied for its central role in regulating gonadotropin-releasing hormone (GnRH) and the reproductive endocrine axis in preclinical and clinical research.

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Description

What is Kisspeptin?

Kisspeptin-10 is the biologically active 10-amino-acid C-terminal fragment of the larger kisspeptin protein, encoded by the KISS1 gene. It is the principal known activator of the GPR54 receptor (also called Kiss1R), and it functions as the master upstream regulator of gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus.

Discovered in the late 1990s and characterized as essential for reproductive function in the mid-2000s, kisspeptin signaling is now recognized as the central trigger that initiates puberty and maintains adult reproductive endocrine function. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism in humans, while gain-of-function mutations cause central precocious puberty.

In research, Kisspeptin-10 has been studied for its ability to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release through the GnRH pathway, its role in restoring reproductive function in hypothalamic dysfunction, its effects on sexual response and limbic system activity in neuroimaging studies, and its potential applications in fertility research.

Research Applications

Areas of Investigation

Endocrine

Reproductive Axis Regulation

The master upstream regulator of GnRH secretion, kisspeptin signaling initiates puberty and controls the pulsatile release of reproductive hormones throughout adult life.

Fertility

Fertility Research

Studied in clinical research for its ability to stimulate LH and FSH release in cases of hypothalamic amenorrhea and as a potential trigger for oocyte maturation in IVF protocols.

Neural

Sexual & Limbic Response

Neuroimaging studies have documented kisspeptin's effects on brain regions involved in sexual processing, emotional regulation, and reward, suggesting roles beyond reproductive endocrinology.

Clinical

Hypogonadism Investigation

Research has explored kisspeptin's potential to restore reproductive function in hypogonadotropic hypogonadism, including in research populations where GnRH itself is ineffective.

Compound Profile

Technical specifications

What is Kisspeptin?

Molecular Profile

Sequence

Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Molecular Formula

C₆₃H₈₃N₁₇O₁₄

Molecular Weight

1302.46 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Reconstituted peptide is most stable when refrigerated and protected from repeated freeze-thaw cycles.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved as a pharmaceutical drug. Sold strictly as a research chemical.

WADA Classification

Not currently listed as a prohibited substance.

Clinical Trial Status

Extensive published research on kisspeptin's role in GnRH regulation, reproductive function, fertility applications, and effects on the limbic and reward systems.

Published Studies

Extensive published research on kisspeptin's role in GnRH regulation, reproductive function, fertility applications, and effects on the limbic and reward systems.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.61%

Purity

Variant

Kisspeptin

Lot #

GLZ-KISSPEPTIN-10MG-A

Labelled

10mg

Actual

9.65mg

Tested

5/11/2026

View COA

Frequently Asked Questions

Common questions about Kisspeptin research

What is Kisspeptin-10?

Kisspeptin-10 is the 10-amino-acid biologically active fragment of the kisspeptin protein, encoded by the KISS1 gene. It is the principal activator of the GPR54 receptor and acts as the master upstream regulator of the reproductive endocrine axis.

What does kisspeptin do in the body?

Kisspeptin neurons in the hypothalamus signal to GnRH neurons, triggering the pulsatile release of GnRH, which in turn stimulates LH and FSH release from the pituitary. This cascade controls the entire reproductive endocrine axis, including puberty initiation and adult reproductive function.

How does kisspeptin differ from GnRH?

Kisspeptin acts upstream of GnRH. Kisspeptin neurons control when and how much GnRH is released, while GnRH directly stimulates the pituitary. This makes kisspeptin a more upstream and physiological signal in some research contexts, including cases where the GnRH neurons themselves are intact but understimulated.

How should Kisspeptin be stored?

Lyophilized kisspeptin should be stored below -18°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 14 days. Avoid freeze-thaw cycles, which degrade peptide structure.

Is Kisspeptin FDA approved?

No. Kisspeptin is not approved as a pharmaceutical drug. It is sold strictly as a research peptide for laboratory purposes only and is not intended for human consumption.

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Kisspeptin

Description