Kisspeptin
-16%
4X Tested - ISO 17025
99.83% View COA
Reproductive Neuropeptide

Kisspeptin

Certificate of Analysis

Kisspeptin-10 is a neuropeptide that activates the GPR54 receptor, studied for its central role in regulating gonadotropin-releasing hormone (GnRH) and the reproductive endocrine axis in preclinical and clinical research.

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Description

What is Kisspeptin?

Kisspeptin-10 is the biologically active 10-amino-acid C-terminal fragment of the larger kisspeptin protein, encoded by the KISS1 gene. It is the principal known activator of the GPR54 receptor (also called Kiss1R), and it functions as the master upstream regulator of gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus.

Discovered in the late 1990s and characterized as essential for reproductive function in the mid-2000s, kisspeptin signaling is now recognized as the central trigger that initiates puberty and maintains adult reproductive endocrine function. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism in humans, while gain-of-function mutations cause central precocious puberty.

In research, Kisspeptin-10 has been studied for its ability to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release through the GnRH pathway, its role in restoring reproductive function in hypothalamic dysfunction, its effects on sexual response and limbic system activity in neuroimaging studies, and its potential applications in fertility research.

Research Applications

Areas of Investigation
Endocrine

Reproductive Axis Regulation

The master upstream regulator of GnRH secretion, kisspeptin signaling initiates puberty and controls the pulsatile release of reproductive hormones throughout adult life.
Fertility

Fertility Research

Studied in clinical research for its ability to stimulate LH and FSH release in cases of hypothalamic amenorrhea and as a potential trigger for oocyte maturation in IVF protocols.
Neural

Sexual & Limbic Response

Neuroimaging studies have documented kisspeptin's effects on brain regions involved in sexual processing, emotional regulation, and reward, suggesting roles beyond reproductive endocrinology.
Clinical

Hypogonadism Investigation

Research has explored kisspeptin's potential to restore reproductive function in hypogonadotropic hypogonadism, including in research populations where GnRH itself is ineffective.

Compound Profile

Technical specifications
What is Kisspeptin?

Molecular Profile

Sequence
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Molecular Formula
C₆₃H₈₃N₁₇O₁₄
Molecular Weight
1302.46 g/mol
Appearance
White lyophilized powder

Form

Lyophilized (freeze-dried)
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.
Shelf Life
24 months from date of manufacture when stored as directed
Sensitivity Notes
Sensitive to heat, light, and moisture. Reconstituted peptide is most stable when refrigerated and protected from repeated freeze-thaw cycles.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
Not approved as a pharmaceutical drug. Sold strictly as a research chemical.
WADA Classification
Not currently listed as a prohibited substance.
Clinical Trial Status
Extensive published research on kisspeptin's role in GnRH regulation, reproductive function, fertility applications, and effects on the limbic and reward systems.
Published Studies
Extensive published research on kisspeptin's role in GnRH regulation, reproductive function, fertility applications, and effects on the limbic and reward systems.
Research Disclaimer
For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
99.83%
Purity
Variant
Kisspeptin
Lot #
GL-2609-024
Labelled
10mg
Actual
10.55mg
Tested
9/14/2026
View COA
(opens in a new tab)
99.69%
Purity
Variant
Kisspeptin
Lot #
KISS10-GL01
Labelled
10mg
Actual
10.62mg
Tested
6/24/2026
View COA
(opens in a new tab)
99.61%
Purity
Variant
Kisspeptin
Lot #
GLZ-KISSPEPTIN-10MG-A
Labelled
10mg
Actual
9.65mg
Tested
5/11/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about Kisspeptin research