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Cognitive Peptide

Semax

4.9 (56 reviews)

Semax is a synthetic heptapeptide analog of ACTH(4-10) developed in Russia, studied for its nootropic, neuroprotective, and neurorestorative properties in preclinical and clinical research.

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Description

What is Semax?

Semax is a synthetic heptapeptide based on a fragment of adrenocorticotropic hormone (ACTH), specifically the sequence ACTH(4-10) with the addition of a Pro-Gly-Pro C-terminal tripeptide that enhances metabolic stability. It was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences.

Semax has been approved in Russia and several CIS countries as a prescription medication for the treatment of stroke, cognitive disorders, and peptic ulcers. It is one of the few peptides with regulatory approval for cognitive applications, though it has not been evaluated by the FDA or EMA.

Research has focused on its effects on brain-derived neurotrophic factor (BDNF) expression, neurotransmitter modulation, and neuroprotection. Semax has shown activity in preclinical models of stroke, traumatic brain injury, and neurodegenerative conditions.

Research-grade Semax is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Brain Protection

Neuroprotection

Studied for protective effects on neurons in models of stroke, traumatic brain injury, and oxidative stress.

Cognition

Cognitive Enhancement

Investigated for its effects on memory, attention, and learning through BDNF upregulation and neurotransmitter modulation.

BDNF

BDNF & Neurotrophin Research

Researched for its ability to increase brain-derived neurotrophic factor expression, supporting neuronal survival and synaptic plasticity.

Neurotransmitters

Neurotransmitter Modulation

Explored for effects on dopaminergic and serotonergic systems in preclinical models.

Compound Profile

Technical specifications

What is Semax?

Molecular Profile

Sequence

MEHFPGP

Molecular Formula

C₃₇H₅₁N₉O₁₀S

Molecular Weight

813.93 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Contains methionine susceptible to oxidation. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not FDA approved. Approved in Russia for stroke, cognitive disorders, and peptic ulcers.

WADA Classification

Not currently specifically listed as a prohibited substance.

Clinical Trial Status

Published studies on BDNF expression, neuroprotection, cognitive enhancement, and neurotransmitter modulation.

Published Studies

Published studies on BDNF expression, neuroprotection, cognitive enhancement, and neurotransmitter modulation.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.68%

Purity

Variant

N-Acetyl Slelank Amidate

Lot #

GLZ-SEMAX-10MG-A

Labelled

10mg

Actual

13.54mg

Tested

2/9/2026

View COA

Frequently Asked Questions

Common questions about Semax research

What is Semax?

Semax is a synthetic heptapeptide based on a fragment of ACTH (4-10) developed in Russia. It is studied for its nootropic, neuroprotective, and neurorestorative properties.

Is Semax approved anywhere?

Yes. Semax is approved in Russia and several CIS countries for the treatment of stroke, cognitive disorders, and peptic ulcers. It has not been evaluated by the FDA or EMA.

How should Semax be stored?

Lyophilized Semax should be stored below -18°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 14 days.

How does Semax differ from Selank?

Both are Russian-developed peptides based on naturally occurring protein fragments. Semax is based on ACTH and focuses on cognitive enhancement and neuroprotection. Selank is based on tuftsin and focuses on anxiolytic and immune-modulating effects.

Is Semax FDA approved?

No. Semax is not approved by the FDA. It is sold as a research peptide for laboratory purposes only.

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Every batch is independently tested, documented, and tied to a specific lot number prior to release. If documentation is missing or inconsistent, we will make it right.

Semax

Description