TB-500
-15%
4X Tested - ISO 17025
99.64% View COA
Regenerative Peptide

TB-500

Certificate of Analysis

TB-500 (Thymosin Beta-4) is a synthetic 43-amino acid peptide derived from a naturally occurring protein involved in cell migration, tissue repair, and new blood vessel formation in preclinical research models.

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Description

What is TB-500?

TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring protein found in nearly all human and animal cells. It is one of the most abundant intracellular proteins and plays a critical role in the regulation of actin, a key component of cellular structure involved in cell movement and tissue repair.

Originally identified in the thymus gland, Thymosin Beta-4 has been extensively studied in preclinical models for its role in promoting cell migration, wound healing, and new blood vessel formation (angiogenesis). TB-500 is distinguished by its low molecular weight and water solubility, which allow it to travel through tissues efficiently in laboratory settings.

Preclinical research has explored TB-500 across wound healing, cardiac tissue recovery, inflammation modulation, and corneal repair. Its primary mechanism involves the sequestration of G-actin monomers and regulation of actin polymerization, essential for cellular motility and tissue remodeling.

TB-500 is not approved by the FDA for any medical use and is prohibited by WADA. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation
Healing

Tissue Repair & Wound Healing

Studied for its ability to promote cell migration and accelerate wound closure in preclinical injury models.
Blood Flow

Angiogenesis & Blood Vessel Formation

Investigated for promoting new blood vessel growth through VEGF upregulation and endothelial cell migration.
Recovery

Inflammation Modulation

Researched for its anti-inflammatory properties and ability to reduce pro-inflammatory cytokine production.
Heart Health

Cardiac Tissue Research

Explored in preclinical models for its potential to support heart muscle recovery following ischemic events.
Flexibility

Musculoskeletal Research

Studied in animal models for effects on tendon, ligament, and muscle repair and flexibility.

Compound Profile

Technical specifications
What is TB-500?

Molecular Profile

Sequence
Ac-SDKPDMAE IEKFDKSKL KKTETQEKN PLPSKETIE QEKQAGES
Molecular Formula
C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight
4,963.44 g/mol
Appearance
White lyophilized powder

Form

Lyophilized (freeze-dried)
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture. Stable at room temperature for up to 3 weeks.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.
Shelf Life
24 months from date of manufacture when stored as directed
Sensitivity Notes
Sensitive to heat, light, and moisture. Contains methionine residue susceptible to oxidation. Keep sealed until use.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
Not approved for human use. Category 2 bulk drug substance.
WADA Classification
Prohibited under class S0 (Non-Approved Substances).
Clinical Trial Status
Extensive preclinical research in animal models covering wound healing, cardiac repair, and tissue regeneration.
Published Studies
Extensive preclinical research in animal models covering wound healing, cardiac repair, and tissue regeneration.
Research Disclaimer
For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
99.64%
Purity
Variant
TB-500
Lot #
GL-2609-038
Labelled
10mg
Actual
Tested
9/23/2026
View COA
(opens in a new tab)
99.38%
Purity
Variant
TB-500
Lot #
TB50010-GL01
Labelled
10mg
Actual
10.58mg
Tested
7/23/2026
View COA
(opens in a new tab)
98.90%
Purity
Variant
TB-500
Lot #
TB50010-GL01
Labelled
10mg
Actual
10.50mg
Tested
6/27/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about TB-500 research