Sermorelin
-16%
4X Tested - ISO 17025
99.58% View COA
Growth Hormone Peptide

Sermorelin

Certificate of Analysis

Sermorelin is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH 1-29), studied for its ability to stimulate the pituitary gland’s release of endogenous growth hormone in preclinical and clinical research.

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Description

What is Sermorelin?

Sermorelin (also known as GHRH 1-29 or GRF 1-29) is a synthetic peptide consisting of the first 29 amino acids of human growth hormone-releasing hormone (GHRH), the shortest fragment that retains the full biological activity of the 44-amino acid parent hormone.

Sermorelin functions as a growth hormone secretagogue. It binds to the GHRH receptor on somatotroph cells in the anterior pituitary, stimulating the synthesis and pulsatile release of the body’s own growth hormone. Because it works through the natural pituitary feedback loop, it is studied as a more physiological alternative to exogenous growth hormone in research models.

Sermorelin was first approved by the FDA in the 1990s as a diagnostic and therapeutic agent for growth hormone deficiency before commercial production was discontinued for business reasons. It has a short half-life of roughly 10 to 12 minutes and has been investigated in aging, sleep, and endocrine research.

Research-grade Sermorelin is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation
GH Release

Growth Hormone Secretion

Studied for its ability to bind the GHRH receptor on pituitary somatotrophs and stimulate the synthesis and pulsatile release of endogenous growth hormone.
Pituitary Function

Endocrine Research

Used as a diagnostic tool in research to assess pituitary growth hormone reserve and the integrity of the GHRH signaling axis.
Aging Research

Aging & Longevity

Investigated in aging models for its effects on growth hormone and IGF-1 levels, which decline with age.
Sleep Research

Sleep & Recovery

Examined for its relationship to slow-wave sleep, during which a large portion of natural growth hormone release occurs.

Compound Profile

Technical specifications
What is Sermorelin?

Molecular Profile

Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Molecular Formula
C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight
3357.9 g/mol
Appearance
White to off-white lyophilized powder

Form

Lyophilized (freeze-dried)
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.
Shelf Life
24 months from date of manufacture when stored as directed
Sensitivity Notes
Sensitive to heat, light, and moisture. The asparagine residue at position 8 is prone to degradation in aqueous solution, so reconstituted material should be used promptly.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
Previously approved as a diagnostic and therapeutic agent for growth hormone deficiency; commercial production has since been discontinued. Research-grade material is sold for laboratory purposes only.
WADA Classification
Growth hormone secretagogues are prohibited under the WADA Prohibited List. Researchers should consult the current list for the most up-to-date status.
Clinical Trial Status
Clinical and preclinical research on growth hormone release, pituitary function, and the GHRH receptor.
Published Studies
Clinical and preclinical research on growth hormone release, pituitary function, and the GHRH receptor.
Research Disclaimer
For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
99.58%
Purity
Variant
Sermorelin
Lot #
GL-2609-036
Labelled
10mg
Actual
10.37mg
Tested
9/14/2026
View COA
(opens in a new tab)
99.79%
Purity
Variant
Sermorelin
Lot #
SERM10-GL01
Labelled
10mg
Actual
10.49mg
Tested
6/24/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about Sermorelin research