MOTS-C
-20%
4X Tested - ISO 17025
99.72% View COA
Longevity Peptide

MOTS-C

Certificate of Analysis

MOTS-c is a mitochondria-derived 16-amino acid peptide encoded within mitochondrial DNA, studied for its effects on metabolic homeostasis, insulin sensitivity, and exercise-induced signaling.

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Description

What is MOTS-C?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid peptide encoded within the mitochondrial genome, making it one of the few known mitochondria-derived peptides (MDPs).

MOTS-c is unique because it is encoded by mitochondrial DNA rather than nuclear DNA, representing a form of mitochondrial-nuclear communication. It is released into the bloodstream where it acts as a signaling molecule that regulates metabolic homeostasis.

In preclinical research, MOTS-c has demonstrated effects on glucose regulation, fatty acid metabolism, and AMPK activation. It has also shown exercise-mimetic properties, with levels increasing during physical activity. Studies in aged mice showed improvements in physical capacity and metabolic function.

MOTS-c is not approved by the FDA for any medical use. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation
Metabolism

Metabolic Homeostasis

Studied for its ability to regulate glucose metabolism and fatty acid oxidation through AMPK pathway activation.
Longevity

Exercise & Aging Research

Investigated as an exercise-responsive factor that declines with age, with potential implications for age-related metabolic decline.
Blood Sugar

Insulin Sensitivity

Researched for improvements in insulin sensitivity and glucose uptake in preclinical models of metabolic dysfunction.
Mitochondria

Mitochondrial Signaling

Explored as a mitochondria-derived peptide that mediates communication between mitochondria and the nucleus.

Compound Profile

Technical specifications
What is MOTS-C?

Molecular Profile

Sequence
MRWQEMGYIFYPRKL R
Molecular Formula
C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight
2,174.58 g/mol
Appearance
White lyophilized powder

Form

Lyophilized (freeze-dried)
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -20°C, desiccated, away from light and moisture.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.
Shelf Life
24 months from date of manufacture when stored as directed
Sensitivity Notes
Sensitive to heat, light, and moisture. Contains methionine residues susceptible to oxidation. Keep sealed until use.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
Not approved for human use. Recently discovered research peptide.
WADA Classification
Not currently specifically listed as a prohibited substance.
Clinical Trial Status
Growing body of preclinical research on metabolic regulation, exercise physiology, insulin sensitivity, and aging.
Published Studies
Growing body of preclinical research on metabolic regulation, exercise physiology, insulin sensitivity, and aging.
Research Disclaimer
For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
99.72%
Purity
Variant
MOTS-C
Lot #
GL-2609-027
Labelled
10mg
Actual
10.63mg
Tested
9/14/2026
View COA
(opens in a new tab)
99.78%
Purity
Variant
MOTS-C
Lot #
GL-2609-028
Labelled
40mg
Actual
42.37mg
Tested
9/14/2026
View COA
(opens in a new tab)
99.57%
Purity
Variant
MOTS-C
Lot #
MOTS10-GL01
Labelled
10mg
Actual
10.53mg
Tested
6/24/2026
View COA
(opens in a new tab)
99.80%
Purity
Variant
MOTS-C
Lot #
MOTS40-GL01
Labelled
40mg
Actual
42.54mg
Tested
7/23/2026
View COA
(opens in a new tab)
99.25%
Purity
Variant
MOTS-C
Lot #
GLZ-MOTS-C-10MG-A
Labelled
10mg
Actual
10.20mg
Tested
3/27/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about MOTS-C research