KPV is a tripeptide made up of lysine, proline, and valine. It corresponds to the C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH) and is studied for its anti-inflammatory properties.

How is KPV different from α-MSH?

KPV is the smallest active fragment of α-MSH. It retains much of the parent hormone's anti-inflammatory activity but does not produce the pigmentation or appetite effects, and it appears to act without binding melanocortin receptors.

How should KPV be stored?

Lyophilized KPV should be stored below -18°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and avoid repeated freeze-thaw cycles.

What solvent is used to reconstitute KPV?

KPV is commonly reconstituted with bacteriostatic or sterile water. Add the solvent slowly down the side of the vial and swirl gently rather than shaking.

No. KPV is not approved as a pharmaceutical drug. It is sold as a research peptide for laboratory purposes only.

-16%

4X Tested - ISO 17025

98.41% View COA

Anti-Inflammatory Peptide

KPV

Certificate of Analysis

KPV is a naturally occurring anti-inflammatory tripeptide derived from the C-terminus of alpha-MSH, studied for its ability to inhibit NF-κB signaling and modulate inflammatory pathways independent of melanocortin receptors in preclinical research.

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Description

What is KPV?

KPV (Lysine-Proline-Valine) is a tripeptide corresponding to the C-terminal sequence, positions 11 to 13, of alpha-melanocyte stimulating hormone (α-MSH). It was first identified as possessing autonomous anti-inflammatory activity by Hiltz and Lipton in 1989.

KPV retains much of the anti-inflammatory activity of its parent hormone while lacking the pigmentation and appetite effects associated with α-MSH. Research indicates it acts through a receptor-independent mechanism, entering cells directly and inhibiting the NF-κB and IκB kinase pathways that drive pro-inflammatory cytokine production.

In preclinical research, KPV has been investigated for its role in intestinal and immune inflammation, including models of colitis where it is taken up by the PepT1 di/tripeptide transporter expressed in inflamed tissue. Its small size and stability have made it a peptide of interest for gut, skin, and immune research.

Research-grade KPV is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Inflammation

Anti-Inflammatory Signaling

Studied for its ability to inhibit NF-κB nuclear translocation and reduce pro-inflammatory cytokine production in cellular models, independent of melanocortin receptors.

Gut Health

Gut & Intestinal Research

Investigated in models of colitis and intestinal inflammation, where KPV is taken up by the PepT1 transporter expressed in inflamed epithelial and immune cells.

Immune Response

Immune Modulation

Examined for its capacity to modulate local and systemic inflammatory responses while preserving the immunomodulatory profile of its parent hormone α-MSH.

Skin Health

Skin & Tissue Research

Researched for potential anti-inflammatory and antimicrobial activity relevant to dermatological and wound-related models.

Compound Profile

Technical specifications

What is KPV?

Molecular Profile

Sequence

Lys-Pro-Val

Molecular Formula

C₁₆H₃₀N₄O₄

Molecular Weight

342.4 g/mol

Appearance

White to off-white lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Reconstituted solution should be protected from repeated temperature changes.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved as a drug. KPV is sold as a research peptide for laboratory purposes only and is not regulated as a pharmaceutical.

WADA Classification

Not currently listed as a prohibited substance. Researchers should consult the current WADA Prohibited List for the most up-to-date status.

Clinical Trial Status

Preclinical research on NF-κB inhibition, intestinal inflammation, PepT1-mediated uptake, and immune modulation.

Published Studies

Preclinical research on NF-κB inhibition, intestinal inflammation, PepT1-mediated uptake, and immune modulation.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

98.41%

Purity

Variant

KPV

Lot #

GL-2609-026

Labelled

10mg

Actual

10.27mg

Tested

9/14/2026

View COA

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99.86%