IGF-1 LR3
-13%
4X Tested - ISO 17025
98.54% View COA
Growth Peptide

IGF-1 LR3

Certificate of Analysis

IGF-1 LR3 is a modified 83-amino acid analog of insulin-like growth factor 1 with enhanced potency and extended half-life, studied for its effects on cell proliferation and growth signaling.

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Description

What is IGF-1 LR3?

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic, modified analog of human IGF-1 consisting of 83 amino acids. It differs from native IGF-1 through two key modifications: a glutamic acid-to-arginine substitution at position 3 and the addition of 13 amino acids at the N-terminus.

These modifications dramatically reduce IGF-1 LR3’s binding affinity for IGF-binding proteins (IGFBPs), which normally sequester and inactivate circulating IGF-1. As a result, IGF-1 LR3 has a significantly longer half-life and greater potency compared to native IGF-1.

In preclinical research, IGF-1 LR3 has been studied for its effects on cell proliferation, protein synthesis, and metabolic regulation. It acts through the IGF-1 receptor (IGF-1R) to activate the PI3K/Akt and MAPK signaling cascades.

IGF-1 LR3 is not approved by the FDA for any medical use. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation
Cell Growth

Cell Proliferation & Growth

Studied for its potent effects on cell proliferation through IGF-1R activation and downstream PI3K/Akt signaling.
Anabolic

Protein Synthesis

Investigated for effects on muscle protein synthesis and anabolic signaling through the mTOR pathway.
Metabolism

Metabolic Research

Researched for effects on glucose uptake, insulin sensitivity, and nutrient partitioning in preclinical models.
Growth Signaling

Growth Factor Signaling

Used as a research tool to study IGF-1R pathway biology, binding protein interactions, and growth factor pharmacology.

Compound Profile

Technical specifications
What is IGF-1 LR3?

Molecular Profile

Sequence
Modified 83-amino acid IGF-1 analog (Arg3 substitution + 13-amino acid N-terminal extension)
Molecular Formula
C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular Weight
9,111.44 g/mol
Appearance
White lyophilized powder

Form

Lyophilized (freeze-dried)
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -20°C, desiccated, away from light and moisture.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.
Shelf Life
12 months from date of manufacture when stored as directed
Sensitivity Notes
Highly sensitive to heat, light, and moisture. Contains multiple disulfide bonds critical for structure. Keep sealed until use.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
Not approved for human use.
WADA Classification
Prohibited under class S2 (Peptide Hormones, Growth Factors).
Clinical Trial Status
Extensive preclinical research on growth factor signaling, cell biology, and metabolic regulation.
Published Studies
Extensive preclinical research on growth factor signaling, cell biology, and metabolic regulation.
Research Disclaimer
For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
98.54%
Purity
Variant
IGF-LR3
Lot #
GL-2609-022
Labelled
1mg
Actual
1.06mg
Tested
9/21/2026
View COA
(opens in a new tab)
98.35%
Purity
Variant
IGF-LR3
Lot #
IGF1-GL01
Labelled
1mg
Actual
1.01mg
Tested
7/28/2026
View COA
(opens in a new tab)
98.50%
Purity
Variant
IGF-LR3
Lot #
IGF1LR3-1-GL01
Labelled
1mg
Actual
1.02mg
Tested
6/24/2026
View COA
(opens in a new tab)
99.16%
Purity
Variant
IGF-LR3
Lot #
White Cap
Labelled
1mg
Actual
.97mg
Tested
4/12/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about IGF-1 LR3 research