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Growth Peptide

IGF-1 LR3

4.8 (23 reviews)

IGF-1 LR3 is a modified 83-amino acid analog of insulin-like growth factor 1 with enhanced potency and extended half-life, studied for its effects on cell proliferation and growth signaling.

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Description

What is IGF-1 LR3?

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic, modified analog of human IGF-1 consisting of 83 amino acids. It differs from native IGF-1 through two key modifications: a glutamic acid-to-arginine substitution at position 3 and the addition of 13 amino acids at the N-terminus.

These modifications dramatically reduce IGF-1 LR3’s binding affinity for IGF-binding proteins (IGFBPs), which normally sequester and inactivate circulating IGF-1. As a result, IGF-1 LR3 has a significantly longer half-life and greater potency compared to native IGF-1.

In preclinical research, IGF-1 LR3 has been studied for its effects on cell proliferation, protein synthesis, and metabolic regulation. It acts through the IGF-1 receptor (IGF-1R) to activate the PI3K/Akt and MAPK signaling cascades.

IGF-1 LR3 is not approved by the FDA for any medical use. All products are sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation

Cell Growth

Cell Proliferation & Growth

Studied for its potent effects on cell proliferation through IGF-1R activation and downstream PI3K/Akt signaling.

Anabolic

Protein Synthesis

Investigated for effects on muscle protein synthesis and anabolic signaling through the mTOR pathway.

Metabolism

Metabolic Research

Researched for effects on glucose uptake, insulin sensitivity, and nutrient partitioning in preclinical models.

Growth Signaling

Growth Factor Signaling

Used as a research tool to study IGF-1R pathway biology, binding protein interactions, and growth factor pharmacology.

Compound Profile

Technical specifications

What is IGF-1 LR3?

Molecular Profile

Sequence

Modified 83-amino acid IGF-1 analog (Arg3 substitution + 13-amino acid N-terminal extension)

Molecular Formula

C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉

Molecular Weight

9,111.44 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -20°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

12 months from date of manufacture when stored as directed

Sensitivity Notes

Highly sensitive to heat, light, and moisture. Contains multiple disulfide bonds critical for structure. Keep sealed until use.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved for human use.

WADA Classification

Prohibited under class S2 (Peptide Hormones, Growth Factors).

Clinical Trial Status

Extensive preclinical research on growth factor signaling, cell biology, and metabolic regulation.

Published Studies

Extensive preclinical research on growth factor signaling, cell biology, and metabolic regulation.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.16%

Purity

Variant

IGF-LR3

Lot #

White Cap

Labelled

1mg

Actual

.97mg

Tested

4/12/2026

View COA

Frequently Asked Questions

Common questions about IGF-1 LR3 research

What is IGF-1 LR3?

IGF-1 LR3 is a modified 83-amino acid analog of human IGF-1 with an arginine substitution at position 3 and a 13-amino acid N-terminal extension. These modifications reduce binding protein affinity, increasing potency and half-life.

How does IGF-1 LR3 differ from native IGF-1?

IGF-1 LR3 has dramatically reduced binding to IGF-binding proteins (IGFBPs) that normally inactivate circulating IGF-1. This results in a longer half-life and greater bioavailability compared to native IGF-1.

How should IGF-1 LR3 be stored?

Lyophilized IGF-1 LR3 should be stored below -20°C, away from light and moisture. It is highly sensitive to degradation. Once reconstituted, refrigerate at 2–8°C and use within 7 days.

Is native IGF-1 FDA approved?

Yes. Native IGF-1 (mecasermin, brand name Increlex) is FDA approved for the treatment of severe IGF-1 deficiency. However, IGF-1 LR3 is a modified analog and is not FDA approved.

Is IGF-1 LR3 FDA approved?

No. IGF-1 LR3 is not approved by the FDA for any medical use. It is prohibited by WADA. All products are sold for research purposes only.

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Every batch is independently tested, documented, and tied to a specific lot number prior to release. If documentation is missing or inconsistent, we will make it right.

IGF-1 LR3

Description