GLP-1 SM
-15%
4X Tested - ISO 17025
98.15% View COA
Metabolic Peptide

GLP-1 SM

Certificate of Analysis

GLP-1 SM is a 31-amino acid GLP-1 receptor agonist originally developed for type 2 diabetes, widely studied for its effects on glucose regulation, appetite suppression, and body weight reduction.

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Description

What is GLP-1 SM?

GLP-1 SM is a synthetic peptide composed of 31 amino acids that shares 94% structural similarity with native human GLP-1 (glucagon-like peptide-1). GLP-1 SM is one of the most extensively studied incretin-based therapies in modern medicine.

The peptide features two amino acid substitutions and a C-18 fatty acid side chain that extends its half-life to approximately 7 days, compared to just 1.5 minutes for native GLP-1. This allows for once-weekly administration in clinical settings.

Semaglutide has been approved by the FDA under multiple brand names for type 2 diabetes and chronic weight management. It works by activating the GLP-1 receptor, which stimulates insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces appetite.

Research-grade GLP-1 SM sold as a lyophilized peptide is not equivalent to FDA-approved formulations and is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation
Blood Sugar

Glucose Regulation

Extensively studied for its ability to stimulate glucose-dependent insulin secretion and suppress glucagon release through GLP-1 receptor activation.
Weight Loss

Body Weight & Appetite

Demonstrated significant weight reduction in large-scale clinical trials through appetite suppression and delayed gastric emptying.
Heart Health

Cardiovascular Research

Evaluated in clinical trials for reduction of major adverse cardiovascular events in patients with type 2 diabetes.
Metabolism

Metabolic Syndrome

Studied for broad metabolic effects including improvements in blood pressure, lipid profiles, and inflammatory markers.

Compound Profile

Technical specifications
What is GLP-1 SM?

Molecular Profile

Sequence
HXEGTFTSD VSSYLEGQAAK *EFIAWLVRGRG
Molecular Formula
C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight
4,113.58 g/mol
Appearance
White lyophilized powder

Form

Lyophilized (freeze-dried)
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.
Shelf Life
24 months from date of manufacture when stored as directed
Sensitivity Notes
Sensitive to heat, light, and moisture. Keep sealed until use.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
FDA-approved as various brand names. Research-grade peptide is not equivalent to approved formulations.
WADA Classification
Not currently prohibited by WADA (subject to change).
Clinical Trial Status
One of the most studied peptides in clinical medicine with hundreds of published studies across metabolic, cardiovascular, and neurological research.
Published Studies
One of the most studied peptides in clinical medicine with hundreds of published studies across metabolic, cardiovascular, and neurological research.
Research Disclaimer
Research-grade product is for laboratory purposes only. Not equivalent to FDA-approved formulations. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
98.15%
Purity
Variant
GLP-1 SM
Lot #
GL-2609-012
Labelled
10mg
Actual
10.08mg
Tested
9/14/2026
View COA
(opens in a new tab)
99.92%
Purity
Variant
GPL SM
Lot #
GLP-1SM10MGA
Labelled
10mg
Actual
13.18mg
Tested
9/3/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about GLP-1 SM research