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Growth Hormone Secretagogue

CJC-1295 no/DAC

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CJC-1295 (without DAC) is a growth hormone-releasing hormone (GHRH) analog studied for its role in stimulating pulsatile GH release, supporting research into recovery, body composition, and tissue repair.

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Description

What is CJC-1295 no/DAC?

CJC-1295 (without DAC), also known as Modified GRF (1-29) or mod GRF (1-29), is a synthetic 29-amino-acid analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The peptide contains four amino acid modifications that protect it from enzymatic degradation while preserving its biological activity.

The “without DAC” designation distinguishes it from CJC-1295 with DAC (Drug Affinity Complex), a related compound modified with a lysine linker that binds to serum albumin to extend its half-life to days. Without DAC, the peptide has a short half-life (approximately 30 minutes), producing brief, pulsatile GH release that more closely mirrors the body’s natural endogenous rhythm.

In preclinical and early clinical research, CJC-1295 (without DAC) has been studied for its ability to stimulate pulsatile growth hormone release through the GHRH receptor, support increases in IGF-1 levels, and contribute to research on recovery, sleep architecture, and body composition. It is frequently studied in combination with the ghrelin mimetic Ipamorelin, which acts on a different receptor to amplify GH release.

Research Applications

Areas of Investigation

GH Signaling

Pulsatile GH Release

Studied for its ability to stimulate brief, pulsatile growth hormone release through the GHRH receptor, more closely mimicking the body's natural endogenous rhythm than longer-acting analogs.

Healing

Recovery & Tissue Repair

Investigated in preclinical models for its role in supporting cellular repair, muscle recovery, and connective tissue regeneration following injury or strain.

Endocrine

IGF-1 Modulation

Research has documented increases in insulin-like growth factor 1 (IGF-1) following GHRH analog administration, a downstream marker of growth hormone activity.

Composition

Body Composition & Sleep

Studied for its effects on lean mass, adipose tissue distribution, and slow-wave sleep architecture in research populations exploring age-related changes in GH signaling.

Compound Profile

Technical specifications

What is CJC-1295 no/DAC?

Molecular Profile

Sequence

Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

Molecular Formula

C₁₅₂H₂₅₂N₄₄O₄₂

Molecular Weight

3367.97 g/mol

Appearance

White lyophilized powder

Form

Lyophilized (freeze-dried)

Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -18°C, desiccated, away from light and moisture.

Storage (Post-Reconstitution)

Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Avoid freeze-thaw cycles.

Shelf Life

24 months from date of manufacture when stored as directed

Sensitivity Notes

Sensitive to heat, light, and moisture. Reconstituted peptide is most stable when refrigerated and protected from oxidation.

Compliance & Clinical Overview

Regulatory & Research Status

FDA Status

Not approved as a pharmaceutical drug. Not regulated as a dietary supplement. Sold strictly as a research chemical.

WADA Classification

Prohibited at all times (in and out of competition) under the World Anti-Doping Agency's S2 category: Peptide Hormones, Growth Factors, Related Substances and Mimetics.

Clinical Trial Status

Preclinical and early clinical research on GHRH analog pharmacokinetics, GH/IGF-1 stimulation, and body composition effects. Most published trial data comes from the with-DAC variant.

Published Studies

Preclinical and early clinical research on GHRH analog pharmacokinetics, GH/IGF-1 stimulation, and body composition effects. Most published trial data comes from the with-DAC variant.

Research Disclaimer

For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics

99.78%

Purity

Variant

CJC-1295

Lot #

GLZ-CJC-1295NO/DAC-10MG-A

Labelled

5mg

Actual

5.45mg

Tested

5/11/206

View COA

Frequently Asked Questions

Common questions about CJC-1295 no/DAC research

What is CJC-1295 (without DAC)?

CJC-1295 without DAC, also called Modified GRF (1-29) or mod GRF (1-29), is a synthetic 29-amino-acid analog of growth hormone-releasing hormone (GHRH). It contains four amino acid modifications that protect it from enzymatic breakdown while preserving its biological activity.

What is the difference between CJC-1295 with DAC and without DAC?

The with-DAC version includes a Drug Affinity Complex (a lysine linker) that binds to serum albumin and extends the peptide's half-life to several days, producing sustained GH elevation. The without-DAC version has a short half-life (approximately 30 minutes), producing brief, pulsatile GH release that more closely mirrors natural endogenous patterns.

How should CJC-1295 (without DAC) be stored?

Lyophilized CJC-1295 should be stored below -18°C, away from light and moisture. Once reconstituted, refrigerate at 2–8°C and use within 14 days. Avoid freeze-thaw cycles, which degrade peptide structure.

Why is CJC-1295 often studied alongside Ipamorelin?

CJC-1295 and Ipamorelin act on different receptors in the GH release pathway. CJC-1295 stimulates the GHRH receptor, while Ipamorelin activates the ghrelin receptor. When studied together, the dual-receptor approach produces a more pronounced GH pulse than either compound alone.

Is CJC-1295 (without DAC) FDA approved?

No. CJC-1295 (without DAC) is not approved as a pharmaceutical drug. It is sold strictly as a research peptide for laboratory purposes only and is not intended for human consumption.

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CJC-1295 no/DAC

Description