GhostLabz 5 Mino 1MQ 10mg vial
-12%
4X Tested - ISO 17025
99.90% View COA
Metabolic Compound

5-Amino-1MQ

Certificate of Analysis

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), studied in preclinical models for its effects on adipocyte metabolism, NAD+ availability, and cellular methylation.

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Description

What is 5-Amino-1MQ?

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in white adipose tissue and liver. It is a quinolinium compound rather than a peptide, and is most commonly supplied as the iodide salt.

NNMT consumes two substrates of metabolic interest: nicotinamide, a precursor in the NAD+ salvage pathway, and S-adenosylmethionine, the cell’s principal methyl donor. Inhibiting NNMT is therefore studied as a way to influence intracellular NAD+ availability, methylation capacity, and downstream sirtuin signaling.

Published preclinical work has examined 5-Amino-1MQ in cultured adipocytes and in diet-induced obese mouse models, where NNMT inhibition was associated with reduced adipocyte size and changes in body composition without a reduction in food intake. Separate research has investigated NNMT inhibition in aged muscle stem cell populations and regenerative capacity.

5-Amino-1MQ is not approved by the FDA or any other regulatory agency. It is sold strictly for laboratory and research purposes only.

Research Applications

Areas of Investigation
Enzyme Inhibition

NNMT Enzyme Inhibition

Used as a research tool compound to inhibit nicotinamide N-methyltransferase and probe its role in tissue-specific metabolic regulation.
Fat Metabolism

Adipocyte Metabolism

Studied in cultured adipocytes and diet-induced obese rodent models for effects on adipocyte size and body composition independent of food intake.
Cellular Energy

NAD+ and Methylation Pathways

Investigated for its effect on nicotinamide recycling through the NAD+ salvage pathway and on S-adenosylmethionine availability for cellular methylation.
Regeneration

Muscle Stem Cell Research

Examined in aged skeletal muscle models, where NNMT inhibition has been linked to changes in satellite cell function and regenerative capacity.

Compound Profile

Technical specifications
What is 5-Amino-1MQ?

Molecular Profile

Sequence
Not applicable (small molecule, not a peptide). IUPAC: 1-methylquinolin-1-ium-5-amine
Molecular Formula
C₁₀H₁₁N₂⁺ (commonly supplied as the iodide salt, C₁₀H₁₁IN₂)
Molecular Weight
159.21 g/mol (cation) | 286.11 g/mol (iodide salt)
Appearance
Yellow to off-white crystalline powder

Form

Lyophilized / crystalline powder
Handling & Shelf Life Guidelines

Storage & Stability

Storage (Pre-Reconstitution)

Store below -20°C, desiccated, away from light and moisture. Short-term transport at ambient temperature is tolerated.
Storage (Post-Reconstitution)
Refrigerate at 2–8°C. For longer storage, aliquot and store below -18°C. Protect solutions from light.
Shelf Life
24 months from date of manufacture when stored as directed
Sensitivity Notes
Hygroscopic and light sensitive. Keep sealed and desiccated until use.
Compliance & Clinical Overview

Regulatory & Research Status

FDA Status
Not approved for human use. Not an approved drug and not recognized as a dietary ingredient.
WADA Classification
Not specifically listed on the WADA Prohibited List. As a non-approved substance it may fall under class S0.
Clinical Trial Status
Peer-reviewed preclinical literature covering NNMT inhibition in adipose tissue, NAD+ and methyl donor metabolism, and aged muscle stem cell function.
Published Studies
Peer-reviewed preclinical literature covering NNMT inhibition in adipose tissue, NAD+ and methyl donor metabolism, and aged muscle stem cell function.
Research Disclaimer
Experimental research compound. For laboratory and research purposes only. Not intended for human consumption.

COA's (Certificate of Analysis)

Third Party Tested by Freedom Diagnostics
99.90%
Purity
Variant
5-Amino-1MQ
Lot #
GL-2609-001
Labelled
10mg
Actual
10.65mg
Tested
9/11/2026
View COA
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99.94%
Purity
Variant
5-Amino-1MQ
Lot #
5AMINO10-GL01
Labelled
10mg
Actual
10.48mg
Tested
7/31/2026
View COA
(opens in a new tab)

Frequently Asked Questions

Common questions about 5-Amino-1MQ research